1) Seeley BM, Denton AB, Ahn MS, Maas CS. Effect of homeopathic Arnica Montana on bruising in face-lifts: results of a randomized, double-blind, placebo-controlled clinical trial. Arch Facial Plast Surg. 2006 Jan-Feb;8(1):54-9.
Conclusion: Double Blinded Controlled study. Patients taking perioperative homeopathic arnica montana exhibited less ecchymosis (bruising), and that difference was statistically significant (P<.05) on postoperative days 1 and 7 after having face lift surgery.
2) Totonchi A, Guyuron B. A randomized, controlled comparison between arnica and steroids in the management of postrhinoplasty ecchymosis and edema. Plast Reconstr Surg. 2007 Jul;120(1):271-4.
Conclusion: Double Blinded Controlled study. Patients taking arnica montanta after rhinoplasty had less edema (swelling) on postoperative 2 when compared to those that did not, and this was statistically significant (p<.0001).
3) Kamenicek, V. et al. [Systemic enzyme therapy in the treatment and prevention of post-traumatic and postoperative swelling]. Acta Chir Orthop Traumatol Cech. 68(1):45-49,2001.
Conclusion: Double Blinded Controlled study. Patients taking Bromelain after internal fixation of fractures of long bones had 12% less edema (swelling) than the control (placebo) group. The circumference of the treated limb was used as a measure of the swelling).
4) Seltzer AP. A double-blinded study of Bromelain in the treatment of edema and ecchymosis following surgical and non-surgical trauma to the face. Eye Ear Nos Throat Mon. 43:54,1964.
Conclusion: Double Blinded Controlled study. Patients receiving Bromelain required 1/3 to 1/2 fewer days to resolve edema (swelling) and ecchymosis (bruising) than the placebo group.
5) Voinchet V, Vasseur P, and Kern J. Efficacy and Safety of hyaluronic acid in the management of acute wounds. American Journal Clinical Dermatology. 206;7(6)353-7.
Conclusion: 43 patients with acute wounds (trauma, surgery, burns) had hyaluronic acid applied to their wounds which provides accelerated healing.
6) McCarty, MF. Glucosamine for wound healing.
Med Hypotheses. 1996 Oct;47(4):273-5.
Conclusion: There is a rapid production of hyaluronic acid by fibroblasts in the early stages of a wound. Increased levels of hyaluronic acid, as observed during fetal wound healing, or as achieved by the topical application of hyaluronic acid during wound dressing, are associated with brisker healing and reduced scarring. Glucosamine availability appears to be rate-limiting for hyaluronic acid synthesis. Thus the administration of adequate amounts of glucosamine by mouth during the first few days after surgery or trauma can be expected to enhance hyaluronic acid production in the wound, promoting swifter healing and possibly diminishing complications related to scarring.
7) Desneves KJ, Todorovic BE, Cassar A, Crowe TC.Treatment with supplementary arginine, vitamin C and zinc in patients with pressure ulcers: a randomized controlled trial. Clin Nutr. 2005 Dec;24(6):979-87. Epub 2005 Nov 15.
Conclusion: Double Blinded Controlled study. Supplementary vitamin C and zinc significantly improved the rate of pressure ulcer healing.